I would like to thank the Dade County Medical Examiner’s Office for putting up with me for a week, and particularly Dr. Charles Wetli, whose patience talking with someone trained in Ophthalmology and Surgery instead of Forensic Pathology was extraordinary. I would also like to thank Dr. Charles Hirsch, Chief Medical Examiner for the City of New York, for his hospitality, and Dr. Jackie Lee for her willingness to share a glimpse into the more personal side of Forensic Pathology.

Last, but not least, I would like to thank Jean Reeds, whose intuitive sense of psychology makes her support, advice, and criticism inordinately valuable.

The cocaine shot into Duncan Andrews’ antecubital vein in a concentrated bolus after having been propelled by the plunger of a syringe. Chemical alarms sounded immediately. A number of the blood cells and plasma enzymes recognized the cocaine molecules as being part of a family of compounds called alkaloids, which are manufactured by plants and include such physiologically active substances as caffeine, morphine, strychnine, and nicotine.

In a desperate but vain attempt to protect the body from this sudden invasion, plasma enzymes called cholesterases attacked the cocaine, splitting some of the foreign molecules into physiologically inert fragments. But the cocaine dose was overwhelming. Within seconds the cocaine was streaking through the right side of the heart, spreading through the lungs, and then heading out into Duncan ’s body.

The pharmacologic effects of the drug began almost instantly.